If the transform's transform() operation is synchronous and always enqueues output immediately, it never signals backpressure back to the writable side even when the downstream consumer is slow. This is a consequence of the spec design that many developers completely overlook. In browsers, where there's only a single user and typically only a small number of stream pipelines active at any given time, this type of foot gun is often of no consequence, but it has a major impact on server-side or edge performance in runtimes that serve thousands of concurrent requests.
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There are some very legitimate and more durable uses of PRF in WebAuthn, specifically supporting credential managers and operating systems.